BA (Oxon), BM BCh (Oxon), PhD, MRCPCH, FRCPath, FHEA
My research focuses on applying modern molecular analytic approaches to human tissue, with the aim of elucidating pathophysiological mechanisms, leading to improved patient stratification frameworks and the identification of novel therapeutic targets. My specific interests are kidney transplantation and ‘inflammatory’ renal diseases including lupus nephritis and ANCA-associated vasculitis. I principally use spatial transcriptomic platforms to interrogate patient kidney biopsy tissue. I lead the Molecular Diagnosis in Renal Pathology (MDiRP) study and have established and currently run two Human Tissue Authority-licensed Research Tissue Banks situated on the Cambridge Biomedical Campus.
Lee CY, McCaffrey J, et al., Profiling immune cell tissue niches in the spatial ”omics” era. J Allergy Clin Immunol. 2025. Mar;155(3):663-677. doi: 10.1016/j.jaci.2024.11.001.
Stewart A., Loudon K., Routledge M., Lee C., Gillman E., Trotter P., McCaffrey J., Posner D., Morris A., Karet F., Clatworthy M., Richoz N. Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test. Sci Transl Med. 2024. PMID: 39321268.
Zhang R. Trotter P., McCaffrey J., et al. Assessment of ‘molecular organ age’ in pre-transplant kidney biopsies. Kidney Int. 2024. 106(2):302-316. doi: 10.1016/j.kint.2024.03.028.
McCaffrey J., Allinson K. Unexplained metabolic acidosis BMJ 2021. https://doi.org/10.1136/BMJ-2021-067276
McCaffrey J. et al. CMV, EBV, JCV and BKV infection and outcome following kidney transplantation in children initiated on a corticosteroid-minimisation immunosuppressive regimen. Pediatr Nephrol 2021. https://doi.org/10.1007/s00467-021-05047-2
McCaffrey J., Shenoy, M. Acute rejection and growth outcomes in paediatric kidney allograft recipients treated with a corticosteroid minimisation immunosuppressive protocol. Pediatr Nephrol 2021. https://doi.org/10.1007/s00467-021-04948-6
McCaffrey J. et al. BK virus infection and outcome following kidney transplantation in childhood. Sci Rep 11, 2468 2021. https://doi.org/10.1038/s41598-021-82160-0
Ortmann B., Burrows N. , Lobb I., Arnaiz E , Wit N., Bailey P., Rayner L., Lombardi O., Peñalver A., McCaffrey J., Seear R., Mole D. Ratcliffe P., Maxwell P., Nathan J. SET1B facilitates activation of the hypoxia response through site-specific histone methylation. Nat Genet 2021.https://doi.org/10.1038/s41588-021-00887-y
McCaffrey J. et al. Recent developments in the detection and management of acute kidney injury. Arch Dis Child. 2017. 102(1):91-96.
McCaffrey J. et al. Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1. Scientific Reports 2017. 7 Article number: 6725 (2017)
Jasim D., Murph S., Newman L., Mironov A., Prestat E., McCaffrey J., Ménard-Moyon C., Rodrigues F., Bianco A., Haigh S., Lennon R., Kostarelos K. The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology. ACS Nano. 2016. 27;10(12):10753-10767
McCaffrey J. et al. The non-immunosuppressive management of childhood nephrotic syndrome. Pediatr Nephrol. 2016. 31(9):1383-402.
McCaffrey J. et al. Towards a biomarker panel for the assessment of acute kidney injury in children receiving intensive care. Pediatr Nephrol. 2015. 30(10):1861-71.
McCaffrey J, Webb N. Towards corticosteroid-free immunosuppression in children. The British Journal of Renal Medicine 2012. 17(4): 19-22
McCaffrey J., Shenoy M. The glomerulonephritides. Paediatrics and Child Health 2012. 22(8): 322-326