MRes, MA (Cantab), PhD
My research interests is broadly centred around how the mitochondria, the so-called powerhouse of the cell, can become dysregulated during different diseases and the impact this has on metabolism and energy regulation in general. I am particularly interested in liver pathologies, and how dysregulation in the liver can integrate with metabolic diseases across other organ systems. Currently I am researching the bioenergetic and metabolic consequences of citrin deficiency, a pan-ethic in-born error of metabolism with a poorly understood disease aetiology. Our research aims to understand how different mutations in the citrin protein can lead to a the wide variety of phenotypes seen in the disease.
Sowton AP, Griffin JL, Murray AJ (2019) Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture. Front Physiol 10: 639. doi:10.3389/fphys.2019.00639.
Sowton AP, Millington-Burgess SL, Murray AJ, Harper MT (2018) Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry. Biochem Biophys Res Commun 503 (4): 2721-2727. doi: 10.1016/j.bbrc.2018.08.031.
Gnaiger E - MitoEAGLE Task Group* (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi: 10.26124/bec:2020-0001.v1
*Author as part of the MitoEAGLE Task Group
Mocciaro G, D'Amore S, Jenkins B, Kay R, Murgia A, Herrera-Marcos LV, Neun S, Sowton AP, Hall Z, Palma-Duran SA, Palasciano G, Reimann F, Murray A, Suppressa P, Sabbà C, Moschetta A, Koulman A, Griffin JL, Vacca M (2022) Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome. Int J Mol Sci 23 (12): 6786. doi: 10.3390/ijms23126786.
Sowton AP, Padmanabhan N, Tunster SJ, McNally BD, Murgia A, Yusuf A, Griffin JL, Murray AJ*, Watson ED* (2020) Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Mol Genet Metab Rep 23: 100580. doi: 10.1016/j.ymgmr.2020.100580.
Tan J*, Virtue S*, Norris DM*, Conway OJ, Yang M, Gribben C, Lugtu F, Kamzolas I, Krycer JR, Mills RJ, Pereira C, Dale M, Shun-Shion AS, Baird HJM, Horscroft JA, Sowton AP, Ma M, Carobbio S, Petsalaki E, Murray AJ, Gershlick DC, Hudson JE, Vallier L, Fisher-Wellman KH, Frezza C, Vidal-Puig A, Fazakerley DJ. Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells. Under review. Available on bioRciv: doi: 10.1101/2022.11.29.516437
O’Brien KA, McNally BD, Sowton AP, Murgia A, Armtiage J, Thomas LW, Krause F.N, Maddalena LA, Francis I, Kavanagh S, Williams DP, Ashcroft M, Griffin JL, Lyon JJ, Murray, AJ (2021) Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress. BMC Biol 19 (1): 265. doi:10.1186/s12915-021-01192-0.