BSc (UCL), PhD
I am interested in the evolution of the malaria parasite, Plasmodium. Plasmodium contains a remnant chloroplast, known as an apicoplast, although it is no longer able to carry out photosynthesis. The apicoplast retains a genome, encoding a small number of proteins. I am examining how these genes are transcribed, and whether transcription and post-transcriptional processing events can offer new targets for novel anti-malarial drugs.
I also work on more conventional photosynthetic organisms, including dinoflagellate algae, which are very important symbionts of coral reefs. In addition, I collaborate with archaeologists, examining the origins of the horse.
Dorrell RG, Drew J, Nisbet RER, Howe CJ (2014) Evolution of chloroplast transcript processing in Plasmodium and its chromerid algal relatives. PLOS Genetics 10:e1004008.
Butterfield ER, Howe CJ, Nisbet RER (2013) An analysis of dinoflagellate metabolism using EST data. Protist 164:218-236
Klinger CM, Nisbet RER, Ouologuem D, Roos D, Dacks, J (2013) Cryptic organelle homology in Apicomplexan parasites: insights from evolutionary cell biology. Current Opinions in Microbiology 16:424-431.
Dorrell RG, Butterfield ER, Nisbet RER, Howe CJ (2013) Evolution: Unveiling early alveolates. Current Biology 23:R1093-6
Nisbet EG, Fowler CMR, Nisbet RER (2012) The regulation of the air: a hypothesis. Solid Earth 3: 87-96.
Bower MA, Campana MG, *Whitten M, Edwards CJ, Spencer M, Jones H, Barrett E, Cassidy R, Nisbet RER, Hill EW, Howe CJ, Binns M (2011) The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish Native mares. Biology Letters 7(2): 316-20.